St. Augustines Political Philosophy Essay Example for Free

St. Augustines Political Philosophy Essay St. Augustine is a fourth century thinker whose weighty way of thinking implanted Christian precept with Neoplatonism. He is popular for being an incomparable Catholic scholar and for his rationalist commitments to Western way of thinking. He contends that doubters have no reason for professing to realize that there is no information. In a proof for presence like one later put on the map by Rene Descartes, Augustine says, â€Å"[Even] If I am mixed up, I am. † He is the principal Western scholar to elevate what has come to be called â€Å"the contention by analogy† against solipsism: there are bodies outer to mine that carry on as I act and that seem, by all accounts, to be supported as mine is fed; in this way, by relationship, I am legitimized in accepting that these bodies have a comparative mental life to mine. Augustine accepts motivation to be an interestingly human intellectual limit that understands deductive realities and intelligent need. Moreover, Augustine embraces an abstract perspective on schedule and says that time is nothing in all actuality except for exists just in the human mind’s dread of the real world. He accepts that time isn't unending in light of the fact that God â€Å"created† it. Augustine attempts to accommodate his convictions about freewill, particularly the conviction that people are ethically liable for their activities, with his conviction that one’s life is fated. In spite of the fact that at first idealistic about the capacity of people to carry on ethically, toward the end he is critical, and feels that unique sin makes human good conduct almost unimaginable: in the event that it were not for the uncommon appearance of an inadvertent and undeserved Grace of God, people couldn't be good. Augustine’s philosophical conversation of freewill is pertinent to a non-strict conversation paying little heed to the strict explicit language he utilizes; one can switch Augustine’s â€Å"omnipotent being† and â€Å"original sin† clarification of fate for the current day â€Å"biology† clarification of fate; the last propensity is obvious in present day mottos, for example, â€Å"biology is fate. †

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purchase custom Malaria exposition Intestinal sickness is an illness which has existed for over fifty years. Jungle fever is accepted to have influenced individuals during the antiquated world. For instance, in 2700 BC, a few instances of jungle fever were accounted for in China. The Roman Empire was additionally tormented by jungle fever. In Rome, it was alluded to as the Roman fever. Consequently, the term jungle fever began from the Medieval Italian word: mala aria meaning terrible air(Randall 24). At first, intestinal sickness was unavoidable in Europe and a few pieces of America particularly in the north, be that as it may, barely any instances of this ailment have been accounted for at present. Since 1896, logical research has been directed to build up the idea of jungle fever. In spite of the fact that jungle fever is firmly connected with neediness, it likewise prompts destitution. This is on the grounds that it prevents monetary advancement in numerous nations particularly in Africa where it is endemic. At present, tropical districts register the most elevated rates of intestinal sickness contaminations, however some mild areas likewise experience jungle fever diseases. Destitution fills in as both a reason and effect of jungle fever. This is on the grounds that poor people need assets to check and fix intestinal sickness. The economy is likewise influenced since numerous assets are directed toward managing jungle fever. Segment progress has likewise deteriorated in places like Africa where jungle fever has not been appropriately dealt with. Other than this, youngster mortality is generally high in jungle fever plagued districts. Reasons for Malaria Plasmodium parasites are answerable for jungle fever contaminations among people, winged creatures, and creatures. In people, jungle fever is brought about by P. falciparum, P. malariae, P. ovale, P. vivax and P. knowlesi(Zimmerman 45). In any case, intestinal sickness diseases are basically brought about by P. Vivax. Then again, P. falciparum is very deadly, and it causes larger part of intestinal sickness passings. People and a few vertebrates go about as middle hosts of parasites. Anopheles mosquitoes fill in as the significant hosts, and they additionally go about as key transmission vectors. Female mosquitoes as a rule transmit the parasites since they feed on blood. Male mosquitoes don't take an interest in transmission of vectors since they eat plant nectars, and they don't depend on blood dinners. Aside from mosquitoes, blood transfusion may likewise prompt transmission of intestinal sickness, yet this happens once in a while. Intestinal sickness frequently repeats among patients who have gotten drug in view of the accompanying variables. At times, a few parasites may not be totally decimated through treatment. Henceforth, they can increase and trigger another disease. This method of contamination is known as recrudescence. Besides, jungle fever re-disease frequently happens when an individual is presented to the parasites after treatment. Backslide is the third method of contamination. It is speific to P. vivax and P. ovale and includes reappearance of blood-stage parasites from inert parasites in the liver(Zimmerman 56). Improvement of jungle fever happens in two stages. The first is known as exoerythrocytic stage, which is portrayed by liver disease. The subsequent level is known as erythrocytic stage, and the parasites taint and harm the red platelets. After a mosquito chomp, the pathogens are transmitted to the liver through the circulatory system. Once in the liver, the living beings separate to yield a large number of merozoites, which escape into the circulation system and taint the red platelets, in this way starting the erthrocytic phase of the life cycle(Sutherland 551). After this, a tainted individual beginnings encountering the manifestations which incorporate the accompanying. Signs and manifestations Manifestations of intestinal sickness incorporate fever, shuddering, heaving, weakness, retinal harm and convulsions(Webb 134). A contaminated individual may encounter perspiring followed by abrupt frigidity particularly for a situation where one is tainted by P.vivax. Now and again, an individual may encounter stomach torment. Other than this, survivors of jungle fever disease may likewise continue psychological disabilities, and this significantly happens among kids. Retinal brightening is an unmistakable side effect among people having cerebral intestinal sickness diseases. At a propelled stage, a jungle fever quiet experience a trance like state, and a patient can without much of a stretch pass on because of genuine body failing brought about by intense harm of platelets. Plasmodium falciparum is more risky than other jungle fever parasites since it causes extreme intestinal sickness that isn't effectively treated. Analysis Blood assessment directed through lab systems is the fundamental method of diagnosing intestinal sickness. A section from blood investigation, pee and spit can likewise be utilized as elective examples for determination of jungle fever, however they are less obtrusive examples. Antigen tests are among the new components for leading clinical assessment for intestinal sickness. In regions where research center tests are missing, investigation of the basic side effects, for example, emotional fever can be utilized to recognize the nearness of jungle fever in a patient. Treatment An intestinal sickness tolerant can recuperate totally on the off chance that the individual gets appropriate medicine. The way jungle fever treatment is directed relies upon the seriousness of the disease. For example, oral medications can be applied in treating typical intestinal sickness contaminations. Hostile to malarial medications are primarily utilized in instances of serious contamination. Bolster measures are additionally significant for genuinely tainted people. Chlroquine and quinine have been regularly utilized, yet moree compelling medications with barely any symptoms have been presented. Utilization of prophylactic medications is only from time to time handy for full-time occupants of intestinal sickness endemic regions(Webb 245). Control Aside from treatment, different systems can be utilized to lessen the spread of jungle fever parasites, and they incorporate the accompanying. Intestinal sickness can best be managed through end of mosquitoes. For instance, vector control activities were fruitful in the annihilation of jungle fever particularly in Europe and America. Depleting of wetlands is likewise significant in this procedure since it decreases the pace of mosquito reproducing. Better sanitation and pesticide DDT have likewise added to a huge decrease of mosquito rearing. Prior to DDT, jungle fever was effectively annihilated or controlled in a few tropical territories by evacuating or harming the reproducing grounds of the mosquitoes or the oceanic natural surroundings of the hatchling stages(Webb 89). Another feasible strategy for controling jungle fever that was as of late found is called sterile creepy crawly procedure. This includes making transgenic mosquitoes that are impervious to jungle fever. This strategy will steadily make mosquitoes less hurtful since the vast majority of them will no longer take an interest in vector transmission. Scientists from Arizona University have likewise made an honorable commitment toward jungle fever disposal by designing mosquitoes that can't be influenced by intestinal sickness. Indoor lingering splashing includes the utilization of bug sprays to dispose of mosquitoes which occupy homes. For this situation, inside pieces of private houses can be splashed with bug sprays, and it has been suggested for individuals living in profoundly swarmed regions. Other than this, mosquito nets are likewise helpful in upgrading assurance of individuals from potential jungle fever diseases. Individuals ought to likewise be sharpened on the best way to manage intestinal sickness related difficulties. End The above conversation uncovers that intestinal sickness has been a test to people for quite a while. For this situation, numerous measures have been taken to manage it. Jungle fever has been wiped out effectively in certain areas, however it has stayed endemic particularly in the third world. This is on the grounds that poor nations are as yet not set up to dispense with it. Aside from causing numerous yearly passing cases, jungle fever has represented an incredible test on the whole world economy. This is on the grounds that numerous assets have been occupied towards managing it. Researcher should, in this way, endeavor to detail economical answers for intestinal sickness. For example, they can grow better medications and antibodies to upgrade the end of intestinal sickness. Last yet more critically, everybody ought to stay submitted in the battle against intestinal sickness. Purchase custom Malaria paper

How A Book Taught Me To Play In The Mud

How A Book Taught Me To Play In The Mud Elizabeth Kolbert, staff writer at The New Yorker, writes about science like a tall cool glass of water. Her writing, to use one of my least favorite book critic phrases is masterful. Actually, masterful is what it really is, and Im not just saying this as someone who loves good science and nature writing. It was Elizabeth Kolbert her clarity, her humor I had in mind when I started That Nature Show, a column about the animals and plants that share my Baltimore backyard. It was her essay in The Sixth Extinction about the expiration of the Panamanian Golden Frog a subject I had not known I gave a flying fig about that inspired me to collect tadpoles with my kids. I became aware of my own nature deficit disorder, the term coined by Richard Louv in his book Last Child In The Woods. When I first saw tadpoles in the spring in the water-filled wheel ruts of the cross-country trail behind my house I screeched to my husband, Leeches! Honey! Run! As a spiritual daughter of Kolbert I can now say I play in the mud. I look carefully at the layers of soil in the creek bed because they might just have a thin layer of iridium from the giant fireball meteorite that wiped out the dinosaurs. That was the fifth extinction. There were four before. And were in one now, in the era some scientists call the Anthropocene, caused by us. In The Sixth Extinction, Kolbert tackles a large, thorny, complex subject: extinction of species, global climate change, and mankinds hand in it, and renders it readable. You dont want to crap your pants. Shes direct were responsible but instead of simply saying mea culpa and moving on to the next Big Box store for socks, forgetting about the Panamanian Golden Frog, Kolbert reminds us it is our responsibility to be smart, scientifically literate, curious, and to keep our heads. Many species have gone the way of the dodo, and we hairy bipeds are not all that special when the view you take is geological. We might go the way of the dodo, the ammonites, the passenger pigeon, and the great auk too, and all our works be reduced to a layer of sediment the thinness of a cigarette paper. Sign up for True Story to receive nonfiction news, new releases, and must-read forthcoming titles. Thank you for signing up! Keep an eye on your inbox.

How to Write an Essay in 5 Steps

What Causes Teenage Drug Abuse - Free Essay Example

Sample details Pages: 4 Words: 1203 Downloads: 1 Date added: 2019/03/22 Category Health Essay Level High school Tags: Drug Abuse Essay Did you like this example? What cause teenage drug abuse Miguel Diaz Saint Michaels College What Causes Teenage Drug Abuse? Nearly half of college students consume illicit drugs. A study done by Newport academy said that in 2016 , 45% of male and 42% of female college students consumed illegal drugs during their academic year. This number has been growing and growing in the last years, and doctors think that is going to keep growing. Don’t waste time! Our writers will create an original "What Causes Teenage Drug Abuse" essay for you Create order There can be a lot of different reasons why this numbers have been growing in the last years but I am going to talk about the ones that in my opinion are the most important ones. Bad parenting is one of the biggest causes of teenage drug abuse. Having trouble at home with your parents will make teenagers wanna evade from reality, and that will cause them to try new things that will cause them a fake relieve.A lot of teenagers have trouble with their parents at this age for multiple reasons, is one of the hardest ages in human live, parents are always looking for the best possible future for their kids, and tennagers just want to have fun and experience new things, they dont tend to put their priorities in college high school grades extracurricular activities jobs while parents focus on this things a lot, and this always bring confrontation between the parts. A study realized by the Pew Research Center showed that only 65% of kids in the United States live with married parents and this has been going down since 1997 when it was 68%, 21% lived with a solo mother and 4% with a solo father. This can be a big cause why teenagers start consuming drugs, having a big parental reference during the teenage age is key for the personal development of the teenagers. At this age (age between 15-20) human beings start and finish developing their personality, and if they start consuming illegal drugs is likely that they will keep doing it until their mid age. Another big cause of teenage drug abuse is curiosity, at this age all tennagers wanna try new things and new experiences and the use of drugs always knocks on their doors. Most tennagers usually start using drugs called connection drugs, that are really cheap and easy acces narcotics that will attract the consumers to the drug world, once consumers start consuming this drugs they will experiment the basic characteristics of the drugs, like highs, head rushes.. and then they will want to consume more strong ones that will cost more money and are more dangerous, this is the reason why this drugs are called connection drugs. Teenage curiosity is one of the most dangerous times in human lives, is a time where teenagers just want to experiment new things without really understanding or acknowledging the causes of them. This can also bring teenagers to another dangerous problems like for example suicide, this is why a lot of schools have started a lot of new programs and activities to prevent suicide in their communities. Another reason that causes teenage drug abuse is stress, this is a really important problem in every teenage live, school grades, getting into college, meeting your group friend expectatives, have a good reputation, being a good athlete are things that most of students care about, and when one of this things dont work the get stressed and they can react in a lot of different ways, one of them is drug abuse to relax and try to stop the anxiety and stress, a article in the Telegraph said that one of every 3 16 years old are turning to cigarettes alcohol or drugs to cope with the pressure of loming exams and coursework deadlines, a new study suggests. This numbers are unbelievably high and need to stop, because the amount of teenage drug abuse keeps growing and growing every generation and it starts sooner and sooner, in 2005 1 of every 6 tennagers used drug abuse and alcohol to evadate from stress now is one of every 3. Teenagers live a very stressful live because they are always doing activities or studying or worrying about multiple things, so in my opinion society should try to understand this and try to be a little more flexible with them, with this I mean giving them more time to assimilate things and preparate for them, in that way students are going to be able to have less anxiety and are not going to recur to this last second reliefs that drugs give them. Another reason that causes teenage drug abuse is peer pressure. None human being has the desire of being a loser or a non like person, in fact we all want to achieve good things in live and be a well known person. Teenagers groups use a lot of group pressure when they want one of their friends to do something, this is a really common way for teenagers to start smoking cigarettes or consuming drugs or alcohol. Trying to act mature and cool is a thing that most teenagers try to do to reflect that they are not little kids anymore and they are ready for the real world, a lot of older people drink and smoke cigarettes this is the reason why teenagers start smoking and drinking, and a lot of times if you are the only one in your group that doesnt smoke or drink you are going to feel out of place, or they are not going to like you the same, so everyone is going to start smoking to dont get their social image down. This is how group pressure works and thats why it is a really effective process. The teenage age is a really hard age, where teens have to find their fit and their social place,it is a age highlighted by mistakes where drug abuse is growing and growing every year for multiple causes of society. It is on our hand and responsibility to stop this causes and try to help as much as we can to our society. Together we all can stop this drug problem. Citations Correspondent, K. D. (2009, January 07). Teenagers turn to alcohol and drugs to cope with school stress. Retrieved from https://www.telegraph.co.uk/news/health/news/4141649/Teenagers-turn-to-alcohol-and-drugs-to-cope-with-school-stress.html Monroe, J. (2018, April 25). 10 Facts About Teen Drug Abuse. Retrieved from https://www.newportacademy.com/resources/substance-abuse/10-facts-teen-drug-abuse/ Monroe, J. (2018, January 19). Use of Drugs and Alcohol in Movies May Fuel Teen Drug Abuse. Retrieved from https://www.newportacademy.com/resources/substance-abuse/use-of-drugs-and-alcohol-in-movies-may-fuel-teen-drug-abuse/ General Feedback Colors: Green: Grammar Yellow: Formatting, citations, and punctuation-type issues Blue: Word order, usage, and form issues (vocabulary, spelling, etc.) Gray: I dont understand-contextual issues make this part confusing. Pink: Delete. You dont need this. Red: Caution: This seems off topic. Monroe, J. (2018, April 25). 10 Facts About Teen Drug Abuse. Retrieved from https://www.newportacademy.com/resources/substance-abuse/10-facts-teen-drug-abuse/ Correspondent, K. D. (2009, January 07). Teenagers turn to alcohol and drugs to cope with school stress. Retrieved fromhttps://www.telegraph.co.uk/news/health/news/4141649/Teenagers-turn-to-alcohol-and-drugs-to-cope-with-school-stress.html New Port study about drugs (put in on apa) https://www.newportacademy.com/resources/substance-abuse/10-facts-teen-drug-abuse/ PEW CENTER STUDY https://www.newportacademy.com/resources/substance-abuse/10-facts-teen-drug-abuse/ telegraph study 1 of every 3 16 years old   https://www.telegraph.co.uk/news/health/news/4141649/Teenagers-turn-to-alcohol-and-drugs-to-cope-with-school-stress.html

Introduction And Executive Summary Renewable Energy

PG Assignment Report Name: Junnan LIU Student number: z5057871 Course code: SOLA 9004 Hydroelectricity Introduction and Executive Summary At the present time, renewable energy is a tendency in the whole world with consume of petroleum and the environment problem. There are a lot of reasons to let Elbawener to use renewable energy, some of them I list as follows: First of all, renewable energy is essential to Elbawener s future economic growth and prosperity in a carbon-constrained world. (Introduction of Renewable energy, CEFC, 2015) This is really a perfect thing for Elbawener. What’s more, renewable energy would help lower Elbawener s and Australia s carbon emissions, this is really good for the environment of†¦show more content†¦Because there has a large river nearby and the technology of hydroelectric is advanced and stability. I will list the details of hydroelectric for this city below. Physical Basis of the Technology So just how do we get electricity from water? Actually, hydroelectric and coal-fired power plants produce electricity in a similar way. In both cases a power source is used to turn a propeller-like piece called a turbine, which then turns a metal shaft in an electric generator, which is the motor that produces electricity. A coal-fired power plant uses steam to turn the turbine blades; whereas a hydroelectric plant uses falling water to turn the turbine. The results are the same. Take a look at this diagram of a hydroelectric power plant to see the details: (Hydroelectric power, Howard Perlman, 2015) As the picture shows above, the principle of hydroelectric is very easy: The fast moving water (kinetic energy) strikes the turbine and they will start moving (mechanical energy) and then the energy is used to run electric generators, and then we could produce power what we need. There are four parts of a typical hydro-power plant which are Dams, Turbines, Generators, Transmission lines. (Beauty of Hydro-power, 2015) Dams: The dam is made on a river to collect water and also serves as a water reservoir. To make water have higher potential energy and also control the water flow through pen stocks. Turbines: Convert the kinetic energy of water into mechanical energy. The

Sample Attachment Proposal free essay sample

I  am  also  highly  indebted  to  my  supervisors  Faisal  Shafait  and  Ilya   Mezhirov,  who  seemed  to  have  solutions  to  all  my  problems. Author The  report  presents  the  three  tasks  completed  during  summer  internship  at  IUPR   which  are  listed  below: 1. Detection    of    headlines    in    document    images    with    black    run ­lengths    and   OCRopus  performance  evaluation  in  detecting  headlines 2. Re ­engineering  the  zone ­classification  module 3. Evaluation  of  different  segmentation  algorithms  performance All  these  tasks  have  been  completed  successfully  and  results  were  according  to   expectations. The  detection   of   headlines  achieved  a  low  error  rate  of  2. 85%  as   against    6. 52    of    previously    used    methods. During    evaluation    of    segmentation   algorithms  XY ­cut  was  found  to  gain  a  lot  by  noise  cleanup,  which  is  an  interesting   result  as  it  strengthen  the  claim  of  XY ­cut  segmentation  algorithm  as  a  suitable   method    for    OCRopus. The    re ­engineering    and    porting    of    zone ­classification   module    to    OCRopus    makes    it    possible    for    OCRopus    to    have    a    text/image   segmentation  if  it  is  required  in  future. Author Abstract OCRopus  :  Introduction Though  the  field  of  optical  character  recognition(OCR)  is  considered  to  be  widely   explored,  the  development  of  an  efficient  system  for  use  in  real  world  situations   still  remains  a  challenge  for  developers. OCRopus  is  a  state ­of ­the ­art  document   analysis  and  OCR  system,  featuring  pluggable  layout  analysis,  pluggable  character   recognition,  statistical  natural  language  modeling,  multi ­lingual  capabilities  and  is   being  developed  at  IUPR. This  being  a  very  big  project,  I  was  assigned  the  tasks  of   developing  tools  for  layout ­analysis  and  evaluation. The  Goals: Following  goals  were  set  as  I  proceeded  in  my  work: 1. Conversion  of  ground ­truth ­data  in  MARG  database  from  XML  format   to  hOCR  micro ­format[1]. 2. Development  of  a  rule ­based  headline  detection  method  using  the  median   black  run ­length  of  the  lines. 3. Development    of    segmentation ­classification    module    and    evaluation    of   performance  of  different  segmentation  algorithms  as  against  noise. 1. XML  to  hOCR: hOCR    is    a    format    for    representing    OCR    output,    including    layout    information,   character    confidences,    bounding    boxes,    and    style    information. It    embeds    this   information    invisibly    in    standard    HTML. By    building    on    standard    HTML,    it   automatically    inherits    well ­defined    support    for    most    scripts,    languages,    and   common    layout    options. Furthermore,    unlike    previous    OCR    formats,    the recognized  text  and  OCR ­related  information  co ­exist  in  the  same  file  and  survives   editing  and  manipulation. hOCR  markup  is  independent  of  the  presentation. Due  to  all  above  qualities  of  hOCR  format,  it  is  highly  desirable  to  have  ground   truth  in  this  format. I  was  assigned  the  task  of  converting  the  MARG  database   ground  truth  into  hOCR  format. For  Ã‚  this  purpose  I  have  written  following  script. Script  Name  :  xml ­to ­hocr Language  Used:  Python Command ­line ­argument  form:  xml ­to ­hocr  FILE. XML FILE. XML  :  The  file  in  XML  format  to  be  converted  into  hOCR  micro  format. Note:    The    script    does    not    take    care    of    latex    characters    yet. It    would    be    an   improvement  to  incorporate  this  feature. 2. Headline  detection  Based  on  black  run ­length  and  its  Ã‚  Ã‚  Ã‚  Ã‚  integration   into  OCRopus: Detection  of  headlines  in  document  images  is  one  issue  that  is  mostly  overlooked   but  yet  is  highly  desirable  to  properly  format  the  output  of  OCR. OCRopus  had  till   now  used  a  rule  based  method  which  used  space  between  lines  as  the  criteria  for   detection  of  headlines. Though  this  method  worked  for  many  images,  it  also  failed   many  times. It  was  an  obvious  observation  that  black  run ­lengths  of  headlines  are   more  than  the  black  run ­length  of  the  normal  line,  and  we  tried  to  build  upon  this concept. We  used  median  black  run  length  of  a  line  as  the  deciding  criteria. The   median  was  used  instead  of  mean  because  mean  run  length  could  have  easily  been   affected  by  the  noise  merging  with  text  and  would  have  produce  errors. The  whole  approach  is  simple  as  discussed  below: 1. Calculate  the  median  black  run ­length  for  the  each  line  on  page. 2. Compare  this  run  length  for  each  line  with  the  lines  below  and  above  it. 3. If    black    run ­length    for   a    line   has    been   found   K1(a    parameter)    times    the   median   run ­length    of  line  below  it,  and  K2(another  parameter)  times  the   median  run ­length  of  the  line  above  it,set  it  as  a  headline. The  value  of  parameters  K1  and  K2  was  to  be  found  experimentally. After  many   times  evaluating  the  performance  of  the  program,  the  value  of  K1  and  K2  has  been   set  to  1. 5  and  1. 1  respectively. We  used  histogram  based  method  to  find  the  median  run ­length. A  histogram  of   the  number  of  occurrences  versus  run ­length  was  calculated,  once  we  have  such  a   histogram  we  normalize  it  with  the  largest  value  of  occurrence. Then  we  calculated   the  cumulative  distribution  function  for  this  normalized  histogram. The  point  when   cumulative  distribution  function  reches  a  value  of  0. 5,  corresponds  to  the  median   runlength. The    program    for   detection    of    headlines    was    written   in   C++    and   used    standard   OCRopus  classes. The  program  has  been  successfully  integrated  into  OCRopus  and Evaluation: We    also    designed    a    tool    which    evaluates    the    performance    of    the    OCRopus    in   detecting    headlines. As    according    to    OCRopus    standards,    this    tool    has    been   developed  to  work  with  files  in  hOCR  micro ­format. This  tool  comprises  of  two   programs: 1. The  first  program  takes  the  OCRopus  output  and  the  corresponding  ground   truth  file  in  hOCR  format  and     outputs  the  total  no  of  false  positives  and false  negatives  which  occurred  in  detection. It  also  outputs  the  total  no  of   true    headlines    which   are    present    in   the    ground ­truth. The    command    line   form  of  this  programs  is:

Story Of An Hour Essays (703 words) - The Story Of An Hour

Story Of An Hour In The story of an Hour, Kate Chopin reveals the complex character, Mrs. Mallard, In a most unusual manner. THe reader is led to believe that her husband has been killed in a railway accident. The other characters in the story are worried about how to break the news to her; they know whe suffers from a heart condition, and they fear for her health. On the surface, the story appears to be about how Mrs. Mallard deals with the news of the death of her husband. On a deeper level, however, the story is about the feeling of intense joy that Mrs. Mallard experiences when she realizes that she is free from the influences of her husband and the consequences of finding out that her new-found freedom is not to be. At First, Mrs. Mallard seems to be genuinely affected by her grief: She wept ar once, with sudden, wild abandonment....When the storm of grief had spent itself she went away to her room alone. SHe would have no one follow her(14). At this point in the story, the reader is able to loo k into the mind of Mrs. Mallard; she now noticed, as she looked from her window, the tops of trees that were all aquiver with the distant song(15). She noticed the there were patches of blue sky showing here and there through the clouds(15). The other characters in the story have one impression of Mrs. Mallard; she seems to have reacted to the terrible news as one would expect, but the reader is aware that a distinct change has come over her. The story unviels its theme at this point: Mrs. Mallard, for the first time in her life, experiences a new-found freedom. Instead of dreading the future without her husband, she saw beyond that bitter moment a long procession of years to come that would belong to her absolutely(15. She could now live her life and be absolutely free of the imposing will of her husband: There would be no one to live for her during the coming years; she would live for herself. There would be now powerful will bending hers in the blind persistence with which men and women believe they have a right to impose a private will upon a fellow creature.(15) Mrs. Mallard had, in that brief moment of illumination(15), stumbled upon a truth: she was now her own person, free from the confines of her husband. She had loved her husband, sometimes(15), but that didn't matter: What could love ....count for in the face of theis possession of self-assertion which she suddenly recognized as the strongest impulse of her being!(15). THE theme of the story unfolds at this point: Mrs. Mallard, through the death of her husband, is able to experience the joy of the realization that she is in control of her own destiny. She is now free, free, free!(15. Mrs. Mallard's new-found freedon is not to be, however, as the story takes an ironic, fatal, twist. On the surface, this story appears to be about how Mrs. Mallard accepts the news of the death of her husband; on a deeper level, however, this story examines how Mrs Mallard accepts the possession of her own being which she recognizes as the strongest impulse of her being(15). As she looked out of her window, she was looking at life as she had never seen it before: she was looking drinking in the very elixer of life(16). SHe had never before looked to the future with any optimisim, only dread. She could hardly live with this new-found joy that she had discovered within herself, and ironically, she would not live with new discovery for long. As the story takes an ironic twist, Mr. Mallard turns the latchkey and walks into the room: he had been nowhere near the scene of the accident. THe realization that her new-found joy was not to be was too much for Mrs. Mallard's weak heart to take, but she had at least lived for a few, brief, shinning momnents in the realization of her new-found f reedom English Essays

Twisted pair cable Essay Example

Twisted pair cable Essay Example Twisted pair cable Paper Twisted pair cable Paper difference methods of electronic communication and transmission used. Communication Devices Switches These are mainly used for local area networks (LAN). The reason behind this is that they can be used to bridge a lot of computers together. They do look like hubs but they can vary in speed. They are more intelligent due to the fact that they can send out packets from a set port. There is advantage of using a network switch, they can be used with an Ethernet cable or a fibre optic cable and they still will work perfectly fine. When connecting a router or a server in an LAN or WAN network it is slightly easier because you would just need one cable which would mostly need to a fibre optic cable, so you can get the maximum rate of transfer speed. Routers They are mainly used for connecting one network to another. They are meant for handling information and forwarding to another network connected to the router. You can either connect using wireless or a cable. Normally an Ethernet cable is used to connect the computer networks. Hubs Also known as a concentrator or a multiport repeater. Used in a star or a hierarchical network setup to connect the station or the cable segments. There are two main types of hubs: passive active. Active takes the incoming traffic, amplifies the signal and then forwards it all the ports. In a passive hub it simply divides the incoming traffic and forwards it. A hub can be used to manage and allow individual port configuration and traffic. Hubs operate on the physical layer of the OSI model and they are protocol transparent. This means that they do have the ability to set upper layer protocols such as IP, IPX or a MAC addresses. Hubs just extend them do not control the broadcast or collision domains. Bridges Used to increase the performance of a network by dividing it into separate collision domains. Even though they are more intelligent than hubs due to the fact that they operate at the Data Link layer of the OSI model, they still are not able to control the upper layer protocols. On a separate segment they store the MAC addressing table of all nodes. Basically it takes the incoming frames and checks the destined MAC address and lookups it up against the store MAC addressing table and decides what to do. If the frame is comes from the same port as the destined port than it simply discards the frame. If the destined location is not known than it will be flooded throughout the outgoing ports and segments. Repeaters -One of the less complex hardware of the networking world, because it basically runs at the physical layer of an OSI model, so it is not aware of the frame formats and upper layer protocols. Repeater basically is used to expand a LAN network over large distance regenerating a signal. When using a repeater remember the 5-4-3 rule which means that a maximum distance between two hosts on the same network is 5. Use only maximum of 4 repeaters in a network and only 3 segments can be populated. Gateways Very intelligent devices, they work at the Transport Layer protocol. This is higher than the Upper Layer protocol. This means that can manage and control IP, IPX and MAC addressing. They allow IPX/SPX clients to IP/TCP uplink network to connect to the internet. A gateway in simple terms is like a post office. All the information is sent to it and then as a post office knows the number of houses in the area in the same way a gateway would know all the ports and direct it there. Cell Phones It is a piece of device which is used by a lot of people. It is a portable version and more advanced version of a normal home phone. It lets you voice calling, text messaging, the some other advanced phones even allow video calling and internet browsing. Cell phone is a full duplex device therefore you can connect it to your computer and use it as a modem even though it would be very slow. The newer released phones are somewhere near capable of the proper modem speeds. DCE DTE devices Data Communication Equipment (DCE) is basically equipment which allows communication with a Data Terminal Equipment (DTE). In another words DTE ends the communication line and a DCE provides the path of communication. An example of an DCE is an modem and a computer is a DTE. Fax Machine A device which allows you to send paper copies using PSTN lines to other people. It can also be used to send memos and other information as well. It uses the phone line to transmit the data that is sent. A fax machine has a sensor to read the data and the end of it. It will encode the black and white that it picks on the paper and moves it to the receiving end. It will compress the data before transmitting it. As soon as it receives the data it decodes and decompresses the data so it can arrange it in the way that it scanned it from the original document. There are a lot of things in a fax machine that allow it to do its function. It consists of a source projecting a light beam, a rotating cylinder and a photo electric cell. It also has paper feed like a printer. E-Mail Email also which is the short form for electronic mail. You can use e-mail to stay in contact with your friend/family even colleagues. It does it by finding out the person you want to email hes email address and then you will send him an email and click send and then that person will receive it. Signal Theory When talking about signal theory data is represented by digital format which is dependent on binary or base 2 principles. Analogue and digital frequencies are used for transmitting signals along a medium link. Analogue records the waveform as they are. Digital on the other hand turns the analogue signals normally to sets of number. Analogue signals can have varying amplitude and frequency. Amplitude analyzes the loudness of the signal and Frequency determines the pitch of the signal. Pitch mostly used to refer to low and high notes. If the frequency is lowered than you get a low note and if the opposite is applied than you get a high note. Bit is a binary digit which represents value of 0 which is normally off and 1 which is normally on. Bit can also be referred to as a electrical pulse which is generated by the inner clock in the control unit or data register. Bit can also be used for digital electronics which is another system that uses digital signals. Manipulation of a bit within the memory of a computer can be kept in a steady level on a storage device as a magnetic tape or disc. Byte which is made up of 8 bits is a unit measurement used for information stored on a computer. Synchronous Asynchronous Communication To sum up synchronous communication it is when interaction with data takes place it is done in real time. On the other hand asynchronous or delayed communication is when any data which is archived or stored and accessed later. It is important to choose the most effective delivery mode because it directly impacts the level of interaction that is going to take place. Synchronous It does not use start or stop bits but instead it synchronizes the transmission speed with receiving and sending end of transmission using the clock signals specifically built for each of the components. After this constant streams of data are transmitted between two sources. Because no start or stop bits are involved data transmission is faster, but more problems occur because if latency takes into effect then the synchronization clock will be out of timing therefore the receiving node will get the wrong timings that have been acknowledged in the protocol sending and receiving data. If this happens then data can be corrupted, missing or even wrong message. There are ways around this which take time. You could use check digits and re-synchronize the clocks so that you can verify that the transmission has been successful and has not been interrupted. Advantages of using synchronous transmission are that lower overhead and more data can be transmitted and data transmission rates are also faster. The drawbacks of using synchronous transmission is obviously more prone to problems, it is more expensive and more complex. Asynchronous Opposite to synchronous it uses start and stop bits to mark the start and end of a transmission, this means that 8 bit ASCII characters would be transmitted using 10 bits because the use of start and stop bits. For example (1)10111111(0) the bracketed out one and zero at the start and end mark the start and end of a transmission. This tells the receiving either the first character is transmitting or finished transmitting. This method of transmission is normally used when data is sent occasionally as opposed to in solid stream. Benefits of using asynchronous data is that it works out cheaper because timing is not that important and it is also simple because both end do not require synchronization. Drawback are that if a large amount of data is to be transmitted it would take a long time this is because a lot of bits are only for control uses they do not contain any useful information. Bandwidth is used to define how much volume a medium can transmit. Basically it is the maximum rate at which data can be transmitted across mediums. The more bandwidth a wire can handle the higher transmission rates can be achieved. It can also high transmission rates for multiple users. But there are restrictions in place such as if a user has been transmitting a lot of data between a period of time then a temporary limit will be put on. This is quite common with ISPs. To stop this happening to you best thing to do is not to download a lot at the same time and also close programs which use the bandwidth continuously. Radio Transmission Radio is a way of transmitting signals using varied tones which convey a message of electromagnetic waves with a frequency. Electromagnetic radiation travels in direction of oscillating electromagnetic fields which go through the air and vacuum of space. Changes in radiated waves such as amplitude, frequency or phase allow information to be carried systematically. If the radio waves pass through electrical conductors the oscillating fields induce an alternating current in the conductor. This could be detected and changed into sound or any other type of signal which is able to carry information. Every radio system has a inbuilt transmitter this is the source which allows electrical energy that produces a alternating current of a desired frequency of oscillation. The inbuilt transmitter also has a system which changes some properties of the energy produced to impress a signal on it. This change could be as simple as turning the signal on or off. Change could be more complex such as alternating more subtle properties such as amplitude, frequency, phase or combination of all three properties. The modulated electrical energy is sent via the transmitter to an antenna. Antenna changes the alternating current electromagnetic waves; this allows the waves to transmit in the air. There are drawbacks of using radio. First is attenuation can happen, this basically means the longer the wave has travelling to get to its destination the more weaker it gets. Most obvious example of this would be someone listening to FM radio in the midlands; the further he goes away from the midlands the more signal gets weaker. Microwave An electromagnetic based wave which has a range or wavelength of up to 30 GHz. Currently microwaves are getting more popular due to advancing technologies. Microwave offers high bandwidth at low cost. Most common problem with microwave transmission is reflection. Microwaves are common used for radar which pickup planes and helicopters flying in the air. Microwaves will hit the plane or helicopter and reflect back and gets calculated giving the position of the flying object. Waves are reflected due to a barrier which stops the wave from going further so it hits the barrier and reflects back. Reflection affects the signal if the reflection is not good then the reflection wont happen therefore a dead or a blank signal will be received. To minimize the effect try staying close the satellite. Wireless protocols such as Bluetooth use microwaves to transmit. Satellite Satellite is a orbiting piece of hardware which has been left floating in the air from big companies like Microsoft, satellite can be used for communication. There are also other types of satellites which are used for spying or used for online maps such as Google maps, Microsoft live maps or another services. Satellites provide high bandwidth solutions. Satellite is categorized as a WAN because it uses high speed long distance communication technology which allows them to connect to computers. Attenuation also affects satellite connection due to the same reason. If a satellite is not in the required position and starts transmitting signal it will not reach television so they might not work properly or correctly. Satellite dish has to be in the same direction as the satellite. Satellite signals reach television using a transmission antenna which is located at an uplink facility. The facility has an uplink satellite dish which would be around 9-12 meters in diameter. The bigger the diameter of the satellite the more accurate signals and better signal strength from the satellite is received. The satellite dish would be pointed towards the satellite and the uplinked signal is received by the transponder at a certain frequency. This frequency is normally C-band (4-8 GHz) or KU-band (12-18 GHz). The transponder then retransmits the signal back to the earth. NTSC, PAL or SECAM are three broadcast standards used through out the world. NTSC is normally used in the US, Canada, Japan, Mexico, Philippines, South Korea and other countries. PAL which stands for Phase Alternating Line is an colour encoding system which is used by over 120 countries in the world. In a few years time most of the countries will stop using PAL and either change to DVB-T SECAM It is sequential colour with memory is the analogue colour television system. SECAM was Europes first colour television standard and France currently uses it. The analogue signals for the three broadcasting types are transmitted via a satellite link scramble or unscramble. The analogue signal is a frequency modulated and transformed for a FM to something called baseband. The baseband fuses the audio and video sub carrier. The audio sub is further demodulated to provide a raw audio signal. Digital TVs that transmit via satellites are normally based on open standards such as MPEG and DVB-S. MPEG which stands for Moving Pictures Experts Group is a compressed format which code moving pictures and associated audio information. There is also MPEG 2 which is a digital television signal which is broadcasted via terrestrial cable and direct broadcast satellite TV systems. DVB-S which stands for Digital Video Broadcasting is a standard for satellite TVs which forward error coding and modulation. It is used by every single satellite that serves a continent. Standards Organizations There are difference types of standard organizations. These are the various types of standard organizations TIA/EIA, RS-232, IEEE, ISO, OSI and Manchester Encoding. ISO/OSI International Standards Organizations Open System Interconnect (ISO/OSI) is the standard model for networking protocols and distributed applications. ISO/OSI defines seven network layers. 1. Physical 2. Data Link 3. Network 4. Transport 5. Session 6. Presentation 7. Application I will be only be explaining in-depth the first network layer: Physical. This layer defines what cable or physical medium to be used. There are lots of different types of cable thinnet, thicknet, TPC, UTP. All of these mediums are functionally the same. The major difference between the various cables is the cost, convenience, installation and maintenance. Converters from one media to another operate at this level. TIA/EIA Telecommunications Industry Association Electronics Industries Alliance (TIA/EIA), state the standards which should be used laying cables in a building or a campus. TIA/EIA describes how a hierarchical topology should be laid out. A system where a main cross connect system is used and connected using a star topology using a backbone cabling through a intermediate or a horizontal cross connect. This type of cabling or similar is also used for laying out telecommunication cables. The backbone cabling method will be used to connect the entrance facilities to the main cross connect. In areas such as office a horizontal cross connect for the consolidation of the horizontal cabling, which extends into a star topology. Maximum stated horizontal cable distance should anywhere between 70M-90M. This applies to TTP (Twisted Pair Cable), but the fibre optic horizontal cabling has a set limit of 90M. IEEE Institute of Electrical and Electronics Engineers allows the development of Electro Technology which in other words applies to electricity applied to technology. Societies like the IEEE Computer Society are subsidiaries of the IEEE itself. This standards organization also publishes journals. Devices such as digital camera need set amount of bandwidth speed so it uses a IEEE plug. Any device that uses the IEEE standard uses a twisted pair cable. Signalling Standards NRZ- It stands for Non Return to Zero. It is a binary code normally used for slow speed synchronous and asynchronous transmission interfaces. Ones is represented as a small voltage and zero is negative voltages. They are transmitted by either by set or constant DC voltages. It also uses additional synchronisation so it dose not lose any bits in the process. NRZ-L Non Return to Zero Level is similar to NRZ, but it not a binary code. Same as NRZ one is represented as small voltage, but zero is also represented as a small voltage but it is not as big voltage as one, Therefore it allows more data to be send without a lot of signal change. NRZ-M Non Return to Zero Mark again similar to NRZ, but one is actually represented by a change in physical state and zero is represented as change in physical state. This basically means that there is no voltage when there is no change in physical state. RS-232 This standard applies to serial data transfer such as the 9 pin serial connecters which are commonly used on a computer motherboard. The data is sent in as time series of bits. Synchronous Asynchronous is both supported by this standard. This standard and states the number of control circuits that can be or need to be used to connect the DCE DTE terminal with one another. Data and control circuits which are signalled from a DTE connected to a DCE or vice versa will always flow and operate in one direction this is called half duplex. Only full duplex allows data to be sent and received in both directions at the same time. Manchester Encoding Data bits which are represented by transitions from a logical state another is called Manchester encoding. This is a digital type encoding. In this encoding the signal is self clocking because the length of every data bit is set by default. Depending on the transition direction the state of the bit can be analyzed.

Euro Zone. Decision Making Process Assignment Example | Topics and Well Written Essays - 3000 words

Euro Zone. Decision Making Process - Assignment Example The European Central Bank is responsible for undertaking monetary policy of the region zone. It is governed by the President and the board comprising of the heads of the central banks of nations. To keep inflation in control accounts for the principle task of the European Central Bank. Without any common representation, fiscal policies and governance of the current union and other decisions are take in close cooperation and association between member nations in the Euro group. It accounts for making the political decisions with regards to the euro and the European Union. Comprising of finance ministers of member states the Euro Group, it also includes national leaders in the decision making when need arises during emergency situations. The project discusses the range of events happening in the Eurozone and steps taken to control them through effective decision making and controlling. Reacting late to the global financial meltdown, the Eurozone has suffered significant losses arising out of rising public debts and unsustainable deficits in the peripheral economies. Different national leaders have responded to the crisis differently. The project analyses the decision making processes used by leaders in countering with the crisis. This is done in terms of the strategies, cultures, psychology and also the different leadership styles applied in the process. Leadership issues concerning the corporate social responsibilities, ethical conducts and leadership styles are analysed in the project. Lastly the effects that these issues could raise on the future of Eurozone are put to analysis. Recent Events- Eurozone Crisis The euro which was introduced in 2002 as the universal currency of the entire European Union was able to c onsolidate a huge trading area across the world and was instrumental in rivalling the dollar for attaining global supremacy. However, along with the accumulation of unsustainable and massive deficits and rising public debt levels in the numerous peripheral economies the viability of the Eurozone was greatly threatened. This triggered the immense debt crisis of the Eurozone. The crisis is also a vivid depiction of the economic interdependence of the European Union coupled with the lack of political integration within the system which was much needed for providing a coordinated monetary and fiscal stimulus to the crisis. France and Germany showed their reluctant efforts to step inside the political vacuum created out of the crisis. On the other hand, even the wealthiest members of the Eurozone called upon the weaker states to implement rigorous austerity measures for dealing with the crisis. However, this was not successful as it led to the great political unrest and crumbled governme nts of countries like Italy, Spain, Portugal and Greece. In spite of many measures to rescue the Euro agreed upon by the leaders of Eurozone volatility prevailing in the markets continued to persist consequently raising questions about the future of the euro (Grauwe, 2010). Analysts have noted that the originally powerful members of the European Union Community like Germany had been initiative and eager to develop a large and competitive Eurozone. Because of this initiative they had also allowed a large number of countries to adopt the euro despite the fact they were not fulfilling the required criteria outlined by Maastricht. However, today all of

The Current State of the Caribbean Is Better Explained Through Essay

The Current State of the Caribbean Is Better Explained Through Reference to Contemporary Rather Then Past Global Relations - Essay Example This report stresses that the very conspicuous feminist changes within the Caribbean would be noted in the visibility of Caribbean women in different occupational positions which were once reserved only for European people and the challenges to a transforming relationship between gender and global capitalism are also highlighted This paper makes a conclusion that globalization and its impact on the Caribbean thus seem to depend on several factors such as improved education that can highlight the particularities and specialties of the Caribbean region and bring out the features that would attract the world. Tourism would be a major reason for which businesses and industries would be willing to invest in the Caribbean and the region remains as an attractive tourist destination, making it a full blown participant in the global economy and the process of globalization. The importance of equal gender relations and the significance of comparative education have been discussed considering that women’s position in society and especially within the Caribbean society in this context could be very important in bringing out the changes in global relations. Caribbean society is changing with the changes of global economy and women’s relations may actually define how the Caribbean society projects itself to the world. The importance of education also should not be undermined as only a modern form of education within the Caribbean would help it to relate to a globalized changing and interlinked society.

Arguments for Vitro Human Embryo Research

Arguments for Vitro Human Embryo Research Mallory Marschall The 14-Day Rule Scientific advancement is accelerating, but current laws and regulations fail to keep up with its progress. This problem leads to several ethical and legal dilemmas in various fields of biology. This problem is especially prominent in embryology. Laboratories focusing on in vitro fertilization have been growing embryos and then implanting them on the seventh day (Hyun et. al 169). Due to recent advances, research labs are currently able to grow embryos in vitro up to 14 days (Hyun et. al 169). Current policies and laws around the world are preventing scientist from continuing their work past 14 days. The Ethics Advisory Board of the United States Department of Health, Education and Welfare first proposed this rule in 1979. The 14-day rule is a regulatory line that limits in vitro human embryo research (Hyun et. al 170). This regulation prevents labs from allowing the embryo to survive and keep growing after 14 days. The line is drawn at 14 days because it stops growth before the prim itive streak appears. In other words, it marks the beginning of gastrulation in humans (Reardon 19). The 14-day rule is a strictly enforced law in Canada, Spain, United Kingdom, Sweden, Denmark, Slovenia, Iceland, South Korea, Australia and New Zealand. In other countries, such as the United States, China, Japan, and India it is not a law but is enforced specifically in all scientific guidelines. Switzerland maintains a strict law that only allows human-embryos to be cultured for 7 days (Hyun et. al 171). The 14-day rule has been used internationally, but due to recent advancements there is now a debate over changing this rule. To solve this current problem, it is important to consider the pros and cons of changing the regulation. There are several benefits of not only continuing in vitro human embryo research but extending the time frame past 14 days. Embryology research has led to new information and advancement in various areas of science. These recent advancements have allowed scientist to understand new aspects of early human development some of which have never been seen before (Reardon 15). This new information is important because it could allow doctors to understand why some pregnancies fail during the early stages of pregnancy (Reardon 15). For example, a recent study has discovered and identified special cells that show up in the embryo around day 10 but disappears by day 12 these cells could lead to new advancements (Reardon 16). This developmental step in embryos was previously unknown. The importance of the research conducted using the 14-day rule can be observed in the new research which is consistently being published. Therefore, even more information could be gathered by extending the time fra me past 14 days. Gaining more knowledge regarding the development of humans could greatly benefit couples who have difficulty conceiving. Another benefit from understanding human embryo development is that it would allow more research in developing human embryonic stem cell-based therapies (Niakan et. al 28). These cells have been used to study hematopoietic tissue for the treatment of various blood disorders and cardiogenic precursors for the treatment of heart and vascular disease (Niakan et. al 28). By continuing in vitro research more advancements could be made toward the treatment or cure of several diseases. The fertility industry could greatly benefit from extending the number of days allowed to grow an embryo in vitro past 14 days. A recent study in a IVF clinic in New York City showed that half of the embryos that are implanted in a mothers uterus doesnt survive (Reardon 16). By continuing to grow embryos in vitro scientist could learn the reason behind this problem and prevent future losses of implanted embryos. Future assisted reproductive technologies could be greatly advanced through the understanding of early human embryo development (Niakan et. al 1). A current argument suggests that studying the development of in vitro human embryos is unnecessary. These groups propose using mouse embryos for in vitro studies instead of human embryos (Reardon 16). Unfortunately, there are several species-specific differences such as the timing of a major wave of genome activation, the patterns of gene expression, the frequency of chromosome missegregation and the patterns of epigenetic modifica tions which make the data collect from mouse embryos less applicable to human studies (Niakan et. al 1). To create and improve new fertility treatments the 14-day rule needs the be evaluated to make room for progress. As stated above, there are several benefits for the allowing in vitro human embryo research to continue. It is critical to understand there are several disadvantages to allowing the current regulation to change. The first issue with extending the time frame of in vitro embryo research is deciding what the next time frame limit should be. There is a moral issue in deciding a new time frame. An important argument to consider is growing an embryo for an extended period could cause the embryo undue distress. Other groups are against embryo research because they believe life starts at the moment of conception, therefore vitro embryo research should be stopped completely. No matter what is decided in the future the most important factor to ensure the success of the future law is to guarantee that the new policy has a clear and legally enforced stopping point for research (Hyun et. al 170). Due to advancements in the embryology field it is now possible to grow an embryo in a laboratory for more than 14 days. The ethical and legal issue of whether to allow scientist to grow an embryo after 14 days needs to be carefully considered. As progress is made laws and regulations need to match. There are several different beliefs regarding this issue and each need to be heard and considered. There are two extreme groups believe that embryo research should be stopped completely or that the research shouldnt have a limit. A larger portion of the science community maintain the idea that committees from around the world should meet and discuss the rule and create a new limits and regulations. The extremely successful 14-day rule was created in a similar manner and the new law should be created using the same method. It is crucial that during these international meeting that all the member reflect on the restriction and the pros and cons of any new regulations (Hyun et. al, 170). The most efficient method to solve this current dilemma is to create open discussion with scientific communities from around the world instead of leaving the decision to an individual government or committee. Work Cited Harper, Joyce C et al. Current Issues in Medically Assisted Reproduction and Genetics in Europe: Research, Clinical Practice, Ethics, Legal Issues and Policy. European Society of Human Genetics and European Society of Human Reproduction and Embryology. European journal of human geneticsà ¢Ã¢â€š ¬Ã‚ ¯: EJHG 21 Suppl 2.Suppl 2 (2013): S1-21. Web. 23 Jan. 2017. Hyun, Insoo, Amy Wilkerson, and Josephine Johnston. Embryology Policy: Revisit the 14-Day Rule. Nature 533.7602 (2016): 169-171. Web. 22 Jan. 2017. Niakan, Kathy K et al. Human Pre-Implantation Embryo Development. Development (Cambridge, England) 139.5 (2012): 829-41. Web. 23 Jan. 2017. Reardon, Sara. Human Embryos Grown in Lab for Longer than Ever before. Nature 533.7601 (2016): 15-16. Web. 26 Jan. 2017.

American Colonists Essay -- American History Religion Essays

American Colonists You wil be amazed to learn that which has been occurring in the American colonies. Chaos reigns where once there existed reverence; rage has displaced peace. Some wick ed force has corrupted the colonists’ hearts against their own king and, therefore, against their own best interests as wel. Moreover, the fuel for this sinful fire, in a large part, emerges from a tiny pamphlet, writen anonymously – and for this and li tle else, I give its author credit for inteligence. If identified, I imagine that this traitor would suffer greatly for the outrageous views he presents in Common Sense, which strikes me as anything but common sense. My first objection to this dreadful work of literature is its blatant misuse of the Biblical reference to Samuel in the atempt to support its groundless claims. Granted, kings impose upon their subjects the danger of succumbing to idolatry – only, of course, if the people seek aid from their king rather than from God. Such horrific temptation would surely justify the colonists’ cause. However, by comparing the colonists’ present situation to that of the Israelites, the author has made a serious blunder. As God’s chosen people, partakers of His original covenant, which rested upon obeying the Commandments, the Israelites commited an atrocious sin by asking for a human ruler rather than relying upon their God, who lived among them. Mankind now, by the Lord’s second covenant, stands upon the grace and salvation offered in Christ Jesus. The law stil applies, but under different circumstances, thus rendering it acceptable to live beneath the rule of a hu man king, so long as the heart and soul depend solely upon the King of kings. In addit ion, the coloquial language offends any... ...r litle about such things. What the author lacks in scriptural wisdom, therefore, he compensates for in more worldly knowledge; for this, some credit must be due. Third, granted, when viewed with detachment, an island ruling a continent over such a prolonged expanse of ocean does appear quite ridiculous. However, t here exist bonds between the colonists and the European nations, from which they claim their heritage, that surpass al distances and circumstances. I am therefore inclined to conclude that either the colonists have gone completely mad over the last centu ry and a half, or circumstances have changed to such an extent that I can no longer deem my former home recognizable. In the former case, let my statements remain as they stand. In the later, alow me to stand corrected in accordance to the present circ umstances and condition of the American colonists. American Colonists Essay -- American History Religion Essays American Colonists You wil be amazed to learn that which has been occurring in the American colonies. Chaos reigns where once there existed reverence; rage has displaced peace. Some wick ed force has corrupted the colonists’ hearts against their own king and, therefore, against their own best interests as wel. Moreover, the fuel for this sinful fire, in a large part, emerges from a tiny pamphlet, writen anonymously – and for this and li tle else, I give its author credit for inteligence. If identified, I imagine that this traitor would suffer greatly for the outrageous views he presents in Common Sense, which strikes me as anything but common sense. My first objection to this dreadful work of literature is its blatant misuse of the Biblical reference to Samuel in the atempt to support its groundless claims. Granted, kings impose upon their subjects the danger of succumbing to idolatry – only, of course, if the people seek aid from their king rather than from God. Such horrific temptation would surely justify the colonists’ cause. However, by comparing the colonists’ present situation to that of the Israelites, the author has made a serious blunder. As God’s chosen people, partakers of His original covenant, which rested upon obeying the Commandments, the Israelites commited an atrocious sin by asking for a human ruler rather than relying upon their God, who lived among them. Mankind now, by the Lord’s second covenant, stands upon the grace and salvation offered in Christ Jesus. The law stil applies, but under different circumstances, thus rendering it acceptable to live beneath the rule of a hu man king, so long as the heart and soul depend solely upon the King of kings. In addit ion, the coloquial language offends any... ...r litle about such things. What the author lacks in scriptural wisdom, therefore, he compensates for in more worldly knowledge; for this, some credit must be due. Third, granted, when viewed with detachment, an island ruling a continent over such a prolonged expanse of ocean does appear quite ridiculous. However, t here exist bonds between the colonists and the European nations, from which they claim their heritage, that surpass al distances and circumstances. I am therefore inclined to conclude that either the colonists have gone completely mad over the last centu ry and a half, or circumstances have changed to such an extent that I can no longer deem my former home recognizable. In the former case, let my statements remain as they stand. In the later, alow me to stand corrected in accordance to the present circ umstances and condition of the American colonists.

Exploring the Relationship Between Cigarette Essay

OBJECTIVES: To determine the relationship between state-specific estimates of youth and adult cigarette smoking prevalences, overall, and after adjusting for cigarette prices and strength of smoke-free air laws. METHODS: Crude relationships were determined using state-specific adolescent and adult smoking estimates from three national surveillance systems conducted during 1997, 1999, or 2000. Weighted leastsquares regression analyses were conducted to assess crude and adjusted relationships between state-specific estimates of adolescent and adult smoking. RESULTS: In each crude analysis conducted, adolescent smoking prevalence was significantly and positively related to adult smoking prevalence. These relationships were attenuated, but generally persisted, after controlling for cigarette prices and strength of smoke-free air laws. CONCLUSIONS: Results support the premise that adult smoking influences adolescent smoking behavior. Funders and policy makers need to consider that an effe ctive youth prevention strategy may be to curb smoking among adults. Introduction Cigarettes are the most common form of tobacco used in the United States, among both youths and adults (1, 2). Interest in preventing adolescent uptake of tobacco use increased substantially during the early and mid-1990’s (3), as adolescent smoking initiation and prevalence increased (1, 4-9). This prompted considerable debate in the public health community about the relative merits of a youth or adult-centered tobacco control approach (10-14). A focus on youth has often been viewed by policy-makers as more politically palatable to the communities they serve; however, many researchers have argued that since the problem of tobacco affects people of all ages, effective solutions must do so as well, thereby favoring a more balanced strategy (10-14). An effective approach would target audiences in every age group, encouraging adults to quit without ignoring the reality that virtually all new tobacco users are children or adolescents. A considerable number of studies have noted relationships between parental and adolescent smoking (15-21). Bauman and colleagues noted that a key distinction in studies of parental and adolescent smoking was to distinguish whether the parents were current, former, or never smokers. When they made such distinctions, they found that the relationship between parental smoking status and adolescent smoking was as strong as that for peer smoking (16-17). Chassin and colleagues found that parental smoking cessation may help to lower the risk for adolescent smoking when the other parent was not a current smoker (20). Farkas and colleagues noted that the earlier parents quit, the less likely their children were to become smokers (21). To test the hypothesis that state-specific smoking prevalence for adolescents and adults would be directly related, we initially studied the relationship using data from the 1997 Youth Risk Behavior Surveillance System and Behavioral Risk Factor Surveillance System (22). We documented a direct relationship, a finding also noted by Males (23). To assess this phenomenon more fully, we conducted similar analyses using data from  additional years and another surveillance system (the National Household Survey on Drug Abuse). Furthermore, because we recognized that cigarette prices and the strength of smoke-free air laws could influence both adolescent and adult smoking prevalences, we also studied the relationship after controlling for these important policy variables (2426). We hypothesized that the relationship between adolescent and adult smoking would be attenuated, but not eliminated, after controlling for these potential covariates. Methods Data Youth and adult smoking data for this study were taken from three nationallycoordinated surveillance systems: 1) the Youth Risk Behavior Surveillance System (YRBSS); 2) the Behavioral Risk Factor Surveillance System (BRFSS); and 3) the National Household Survey on Drug Abuse (NHSDA). The YRBSS provides state-specific adolescent data on public high school students between the approximate ages of 14 to 18 years. For this study, we used the following measures of adolescent smoking from YRBSS: current smoking prevalence, frequent cigarette use, youth ever smoking, and youth ever-daily smoking. The 1997 and 1999 YRBSS define current smoking prevalence (current cigarette use) as having smoked on at least 1 of the 30 days preceding the survey, and frequent cigarette use as having smoked  on at least 20 of the 30 days preceding the survey. The 1997 and 1999 YRBSS define youth ever smoking (i.e. lifetime cigarette use) as having ever tried cigarette smoking, even one or two puffs (6, 27). The 1999 YRBSS defines youth ever-daily smoking as having ever smoked at least 1 cigarette every day for 30 days (27). Weighted YRBSS data were published for 24 states in 1997, and for 22 states in 1999. The Centers for Disease Control and Prevention (CDC) weighted these statespecific estimates to adjust for nonresponse and varying probabilities of selection. The data are considered to be representative of all public high school students (grades 9-12), in  the respective states. In our analyses, we only included data from states with weighted YRBSS data. State-specific sample sizes ranged from 1,325 to 8,636 participants in 1997, and from 1,248 to 7,125 participants in 1999 (6, 27). Standard errors for these weighted 1997 and 1999 YRBSS data were provided by the Centers for Disease Control and Prevention, and were used to estimate variances for analyses. The BRFSS provides state-specific estimates of major risk behaviors among adults aged 18 years and older. Adult current smoking and adult ever smoking measures were included as independent predictor variables from 1997 and 1999 BRFSS data. In the 1997 and 1999 BRFSS, current smokers were those who had ever smoked at least 100 lifetime cigarettes and who currently smoked every day or some days. Adult ever smoking was defined by the 1997 and 1999 YRBSS as having ever smoked 100 lifetime cigarettes. We used adult BRFSS data from all states for which we also had YRBSS data, which were 24 states in 1997 and 22 states in 1999. State-specific sample sizes ranged from 1,595 to 3,596 participants in 1997, and from 1,633 to 5,011 participants in 1999 (28-29). The NHSDA provides state-specific adolescent and adult data on substance abuse for adolescents between the ages of 12 to 17 years, adults between the ages of 18 to 25 years (referred to below as young adults), and adults greater than or equal to 26 years (referred to below as adults). In the 1999-2000 NHSDA, current smokers were those who smoked all or part of a cigarette on at least one of the 30 days preceding the survey. Representative samples were drawn from all 50 states and the District of Columbia, with sample sizes ranging from 900 to 1,030 in 42 states and the District of Columbia, and from 3,600 to 4,630 in 8 states. About one-third of each sample represented each age category: 12 to 17 years; 18 to 25 years; and >= 26 years (30). State-specific estimates for price, as of November 1st of each year, were taken from The Tax Burden on Tobacco (31). The average price of a pack of cigarettes was constructed by using weighted averages for a pack of 20 cigarettes based on the prices of single packs, cartons, and vending machine sales, where the weights are the national proportions of each type of sale. These prices are inclusive of state level  sales taxes applied to cigarettes, but are exclusive of local cigarette taxes. Because the price published is as of November 1st, and because the surveys are conducted throughout the year, we created a weighted average annual cigarette price measure by subtracting state and federal excise taxes from the current year’s price and the previous/following year’s price and weighting the pre-tax prices accordingly. Average federal and state excise taxes for the whole year were calculated and added to the weighted average pre-tax price. Data on state-specific smoke-free air legislation were compiled to construct a smoke-free air (SFA) legislation index, using a multi-step process. In itially, these legislative data were taken from the American Lung Association’s ‘State Legislated Actions on Tobacco Issues’ (SLATI) system, and the Centers for Disease Control and Prevention’s ‘State Tobacco Activities Tracking and Evaluation’ (STATE) system. We then contracted with the MayaTech Corporation to validate initial coding, and expand upon our initial categorization scheme by incorporating legislative information on additional locations, such as schools, recreational facilities, and cultural facilities. The state-specific SFA index values were constructed from ratings given to each state, based upon the levels of restriction provided for the following 10 locations in 1997, 1999, and 2000: private worksites, health facilities, restaurants, recreational facilities, cultural facilities, retail/grocery stores, shopping centers, public transit, public schools, and private schools. SFA ratings were summed for each of these 10 locations, and additional weighting was given to 6 designated youth-oriented locations (restaurants, recreational facilities, cultural facilities, shopping centers, public schools, private schools), which were multiplied by 2 prior to summation. After the ratings were summed, 20% of this total SFA score was then subtracted for the existence of any state preemption clauses. The calculation of the subtracted preemption percentage was based upon the average estimated percentage of states with SFA preemption in relevant youth-oriented categories, as described in a paper by Chriqui et al (2002) (32). Preemption clauses prevent a local area, within a state, from enacting  smoke-free ordinances that are stronger or more protective than state smoke-free air laws. Statistical Analysis Weighted least-squares regression analyses were conducted using SPSS software. Regression analyses of adult smoking measures, as the independent predictor variables, on adolescent smoking measures, as the dependent outcome variables, were conducted  for BRFSS, YRBSS, and NHSDA data. Analyses with YRBSS data were conducted overall and by gender (male, female). All regression analyses were weighted by the reciprocal of the variance of the dependent variables. Average price of a pack of cigarettes and strength of smoke-free air legislation were included as potential covariates in adjusted weighted least squares regression analyses. Crude and adjusted beta coefficients were calculated and reported, along with standard errors, r-squared values, and statistical probabilities (p-values). Additional weighted least-squares regression analyses were conducted to further adjust for income disparity. These analyses did not produce noticeably different results for youth-adult data; therefore, income disparity was not considered relevant for adjustment. Results Table 1 presents crude and adjusted results from the weighted least-squares regression analyses of youth and adult smoking measures. In each crude analysis conducted, adolescent smoking prevalence was significantly and positively related to adult smoking prevalence. These relationships were attenuated, but generally persisted, after controlling for cigarette prices and strength of smoke-free air laws. Adjusted overall relationships for 1997 YRBSS and BRFSS data, between youth-adult current smoking prevalence and frequent use, were attenuated; but remained significant. This attenuated, but significant, relationship persisted among males for current smoking  prevalence (with borderline significance among females), and among both males and females for frequent use. Crude relationships between youth-adult current smoking prevalence and frequent  use were significant for 1999 YRBSS and BRFSS data, and adjusted relationships remained significant among females for current prevalence an d frequent use. Crude relationships for NHSDA data from all states and the District of Columbia were also highly significant for youth, young adult, and adult smoking in 1999-2000 (See also: Figure 1). Adjusted relationships for 1999-2000 NHSDA data also remained significant for all youth, young adult, and adult smoking data. Table 2 presents results from additional weighted least-squares regression analyses that were conducted to explore a possible relationship between youth and adults with respect to measures of smoking initiation. These analyses, using 1997 YRBSS and BRFSS data, showed a significant adjusted relationship between youth ever-smoking and adults ever-smoking at least 100 cigarettes. Analyses using 1999 YRBSS and BRFSS data showed significant crude and adjusted relationships between youth ever-daily smoking and adults ever smoking at least 100 cigarettes. Discussion These analyses were conducted to determine the relationship between statespecific estimates of youth and adult cigarette smoking prevalence, overall, and after adjusting for important policy covariates. In each crude analysis conducted, adolescent smoking prevalence was significantly and positively related to adult smoking prevalence. After adjustment, the adolescent-adult relationship was attenuated, but remained significant, for: 1997 overall and male current prevalence; 1997 overall, male, and female frequent use; 1999 female current prevalence and frequent use; and all age groups tested using 1999/2000 NHSDA data. Therefore, the relationships generally persisted after controlling for two important policy variables, price and strength of smoke-free air  legislation. Adjusted analyses, using 1997 and 1999 YRBSS and BRFSS data, also showed a significant relationship between the following measures of smoking initiation: youth ever smoking and adults ever smoking at least 100 cigar ettes; and youth ever-daily smoking and adults ever smoking at least 100 cigarettes. There are several limitations regarding these analyses. Results for the YRBSS/BRFSS data may be influenced by the relatively small number of states with weighted data used in analyses. There were 24 states with weighted YRBSS data in 1997, and 22 states with weighted YRBSS data in 1999. BRFSS data from 1997 and 1999 were only used for the same number of corresponding states with weighted YRBSS data in both respective years. The ecological fallacy may also be involved, since smoking behavior data were drawn and analyzed from state-specific population data. Other variables, such as relationship quality between adolescents and parents, may mediate the relationship between adolescent and adult smoking prevalence. Further research is needed to explore additional variables, which cannot be ruled out by these analyses, and may affect the state-specific relationship between adolescent and adult cigarette smoking. Results are consistent with the notion that adult smoking influences adolescent smoking. Findings are also consistent with parental literature, suggesting that youth behavior models adult behavior, and other research, suggesting that if adults quit youth may be less likely to smoke (16, 17, 19-21). These data support the belief that efforts to prevent initiation and promote quitting, among both adolescents and adults, would be included as key components of an optimal tobacco control strategy and an effective public health effort to reduce tobacco-related mortality and morbidity. An optimal tobacco control strategy would also include a component to protect non-smokers from  environmental tobacco smoke. Glantz and Jamieson have proposed that tobacco control efforts directed at adolescents and young adults need to also emphasize smoke-free air policies, which encourage smoking cessation among  youth, as well as adults (26). Research suggests that population tobacco control strategies that influence adult smoking, like price and smoke-free air, also influence youth smoking (33-38). Therefore, these strategies have a two-for-one effect. This lends further weight to the contention that reducing adult smoking is an important strategy to reduce the uptake of smoking among youth. Public health researchers have an important role in explaining why an emphasis on adult cessation is necessary, and why it does not imply any neglect of youth smoking. The public health response to curbing the tobacco-related health burden should be evidenced based, rather than simply popular. References 1. Centers for Disease Control and Prevention. Youth Tobacco Surveillance, United States, 1998-1999. MMWR Morb Mortal Wkly Rep. 2000;49(SS-10):1-44. 2. U.S. Department of Health and Human Services. Women and Smoking: A report of the Surgeon General. Public Health Service. Office of the Surgeon General. Rockville, MD. 2001. 3. Department of Health and Human Services. Food and Drug Administration. 21 CFR Part 801, et al. Regulations Restricting the Sale and Distribution of Cigarettes and Smokeless Tobacco to Protect Children and Adolescents; Final Rule. Federal Registrar; 61(168): August 28, 1996. 4. Centers for Disease Control and Prevention. Youth Risk Behavior Surveillance – United States, 1993. MMWR Surveillance Summaries. March 24, 1995/44(SS-1); 1-55. 5. Centers for Disease Control and Prevention. Youth Risk Behavior Surveillance – United States, 1995. MMWR Surveillance Summaries. September 27, 1996/ 45(SS-4); 1-83. 6. Centers for Disease Control and Prevention. Youth Risk Behavior Surveillance – United States, 1997. MMWR Surveillance Summaries. August 14, 1998/47(SS3); 1-89. 7. Substance Abuse and Mental Health Services Administration. Summary of Findings from the 2000 National Household Survey on Drug Abuse. Office of Applied Studies, NHSDA Series H-13, DHHS Publication No. (SMA) 01-3549. Rockville, MD, 2001. 8. Centers for Disease Control and Prevention. Incidence of Initiation of Cigarette Smoking – United States, 1965-1996. MMWR 1998; 47:837-840. 9. Johnston, LD, O’Malley, PM, Bachman, JG. Monitoring the Future National Survey Results on Drug Use: 1975-2000. Volume I: Secondary School Students. US Department of Health and Human Services, National Institute on Drug Abuse. NIH Publication No. 01-4924; August 2001. 10. Myers ML. Adults Versus Teenagers: A False Dilemma and a Dangerous Choice. Tobacco Control. 1999;8(3):336-338. 11. Glantz SA. Preventing Tobacco Use – The Youth Access Trap. American Journal of Public Health. 1996;86(2):155-156. 13 12. Hill D. Why We Should Tackle Adult Smoking First. Tobacco Control. 1999;8(3):333-335. 13. McNeill A. Why Children Start Smoking: The Need for a Comprehensive Tobacco Control Policy. British Journal of Addiction. 1992;87(1):24-25. 14. Bayer R, Kiesig V. Is Child-Centered Tobacco Prevention a Trap? American Journal of Public Health. 2003:93(3):369-370. 15. Jacobson PD, Lantz PM, Warner KE, Wasserman J, Pollack HA, Ahlstrom AK. The Social Context of Adolescent Smoking. Combating Teen Smoking Research and Policy Strategies. Ann Arbor: The University of Michigan Press;2001:79114. 16. Bauman KE, Foshee VA, Linzer MA, Koch GG. Effect of Parental Smoking Classification on the Association Between Parental and Adolescent Smoking. Addictive Behaviors. 1990;15(5):413-422. 17. Bauman KE, Carver K, Gleiter K. Trends in Parent and Friend Influence During Adolescence: The Case of Adolescent Cigarette Smoking. Addictive Behaviors. 2001;26(3):349-361. 18. Bailey SL, Ennett ST, Ringwalt CL. Potential Mediators, Moderators, or Independent Effects in the Relationship Between Parents’ Former and Current Cigarette Use and Their Children’s Cigarette Use. Addictive Behaviors. 1993;18(6):601-621. 19. Chassin L, Presson CC, Todd M, Rose JS, Sherman SJ. Maternal Socialization of Adolescent Smoking: The Intergenerational Transmission of Parenting and Smoking. Developmental Psychology. 1998;34(6):1189-1202. 20. Chassin L, Presson C, Rose J, Sherman SJ, Prost J. Parental Smoking Cessation and Adolescent Smoking. Journal of Pediatric Psychology. 2002;27(6):485-496. 21. Farkas AJ, Distefan JM, Choi WS, Gilpin EA, Pierce JP. Does Parental Smoking Cessation Discourage Adolescent Smoking?. Preventive Medicine. 1999; 28(3): 213-218. 22. Giovino GA. Development of a State Tobacco Database for the Robert Wood Johnson Foundation’s ImpacTeen Study. Presentation at â€Å"Tobacco-Free Future: Shining the Light,† the Fifth Annual National Conference on Tobacco and Health. Kissimmee, Florida; August 24, 1999. http://www.impacteen.org/generalarea_PDFs/giovino0899.pdf. 23. Males MA. Smoked: Why Joe Camel is Still Smiling. Monroe, Maine: Common Courage Press: 1999. 14 24. Chaloupka FJ and Grossman M. Price, Tobacco Control Policies, and Youth Smoking. NBER Working Paper 5740, 1996. 25. Taurus JA and Chaloupka FJ. Price, Clean Indoor Air Laws, and Cigarette Smoking: Evidence from Longitudinal Data for Young Adults. NBER Working Paper 6937. Cambridge: National Bureau of Economic Research, 1999. 26. Glantz SA, Jamieson P. Attitudes Toward Secondhand Smoke, Smoking, and Quitting Among Young People. Pediatrics. 2000;106(6):E82. 27. Centers for Disease Control and Prevention. Youth Risk Behavior Surveillance – United States, 1999. 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Chaloupka F, Wakefield M, Czart C. Taxing Tobacco: The Impact of Tobacco Taxes on Cigarette Smoking and Other Tobacco Use. In: Rabin RL Sugarman SD, editors. Regulating Tobacco. New York. Oxford University Press; 2001. p. 39-72. 34. Jacobson PD, Zapawa LM. Clean Indoor Air Restrictions: Progress and Promise. In: Rabin RL Sugarman SD, editors. Regulating Tobacco. New York. Oxford University Press; 2001. p. 207-245. 35. Fichtenberg CM, Glantz SA. Effect of Smoke-Free Workplaces on Smoking Behaviour: Systematic Review. BMJ. 2002;325(7357):174-175. 15 36. Wasserman J, Manning WG, Newhouse JP, Winkler JD. The Effects of Excise Taxes and Regulations on Cigarette Smoking. Journal of Health Economics. 1991;10(1):43-64. 37. Ohsfeldt R, Boyle RG, Capilouto EI. Tobacco Taxes, Smoking Restrictions, and Tobacco Use. NBER Working Paper 6486. Cambridge: National Bureau of Economic Research, 1998. 38. Wakefield MA, Chaloupka FJ, Kaufman NJ, Orleans CT, Barker DC, Ruel EE. 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Drug Development Of The Drug Imatinib - 1050 Words

TRM6002 Essay 2 – Drug Development State what the target for the drug imatinib is, and why that target was a good choice for a drug discovery project. Summary/Abstract: Until the 1990’s, drug discovery relied on forward pharmacology where trial and error produced medications that were usually involved in changing DNA synthesis and/or cell division. These medications were efficacious, but had issues with systemic toxicities due to their non-selectivity of diseased cells or disease causing proteins. With the discovery of specific genetic changes that occur in Chronic Myeloid Leukemia, a haematological malignancy, a target was identified which was only seen in diseased cells; thus, rational drug design came about. Imatinib is the first medication of rational drug design with action only in diseased cells. Introduction: Historically, drug discovery projects were aimed at developing drugs that were involved in changing DNA synthesis and/or cell division. These medications included alkylating agents which were very effective but due to the large range of non targeted action within the body, had multiple side effects and toxicities. Since the discovery of specific and varied genetic changes that can occur within cancerous cells, the approach to drug development has changed significantly. Imatinib was one of the first drugs developed where its site of action was only on diseased but not on non-diseased cells. Discussion: Drug discovery programs start when there is aShow MoreRelatedChronic Myeloid Leukemia1139 Words   |  5 PagesRegarding our recent inquiry as to the viability of an Abl-Bcr inhibitor and the marketability thereof, it is of prudent management to discern the separation between our drug candidate and those drugs currently existing in the market, and evaluating the ease of development as well as long-term payoffs of said inhibitor. 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